Varaico: Literature-Extracted Genetic Variants

APC

6,282 papers

RefSeq Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional acti...

Pfam Domains

APC_N_CCaa 4–55UCSCCoiled-coil N-terminus of APC, dimerisation domain

Suppressor_APCaa 131–207UCSCAdenomatous polyposis coli tumour suppressor protein

APC_repaa 393–466UCSCAdenomatous polyposis coli (APC) repeat

Armaa 512–553UCSCArmadillo/beta-catenin-like repeat

Armaa 649–689UCSCArmadillo/beta-catenin-like repeat

Armaa 691–731UCSCArmadillo/beta-catenin-like repeat

Gene Aliases

HGNC Name

APC regulator of Wnt signaling pathway

HGNC Alias Symbols

DP2; DP3; DP2.5; PPP1R46

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000038.6

p.D1871N

c.5611G>A

Surrounding Variants

1 paper

NM_000038.6

p.D1871G

c.5612A>G

1 paper

NM_000038.6

p.D1870G

c.5609A>G

2 papers

NM_000038.6

p.D1871D

c.5613T>C

1 paper

NM_000038.6

p.V1872I

c.5614G>A

1 paper

NM_000038.6

p.V1872D

c.5615T>A

1 paper

NM_000038.6

p.D1869H

c.5605G>C

2 papers

NM_000038.6

p.D1868G

c.5603A>G

1 paper

NM_000038.6

p.D1873E

c.5619C>A

1 paper

NM_000038.6

p.D1873E

c.5619C>G

1 paper

NM_000038.6

p.D1868N

c.5602G>A

2 papers

NM_000038.6

p.F1867L

c.5601T>A

2 papers

NM_000038.6

p.F1867L

c.5601T>G