Varaico: Literature-Extracted Genetic Variants

Gene:APOE
Variant:p.A277T

APOE

2,396 papers

RefSeq Summary

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich li...

Pfam Domains

Apolipoproteinaa 81–288UCSCApolipoprotein A1/A4/E domain
Apolipoproteinaa 81–288UCSCApolipoprotein A1/A4/E domain

Gene Aliases

HGNC Name

apolipoprotein E

HGNC Previous Symbol

AD2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
4 papers
NM_000041.4
p.A277T
c.829G>A
Surrounding Variants
1 paper
NM_000041.4
p.R278S
c.832C>A
2 papers
NM_000041.4
p.R278C
c.832C>T
1 paper
NM_000041.4
p.Q276*
c.826C>T
5 papers
NM_000041.4
p.F275F
c.825C>T
1 paper
NM_000041.4
p.R278H
c.833G>A
1 paper
NM_000041.4
p.L279P
c.836T>C
1 paper
NM_000041.4
p.A274V
c.821C>T
2 papers
NM_000041.4
p.K280Q
c.838A>C
1 paper
NM_000041.4
p.A274T
c.820G>A
1 paper
NM_000041.4
p.A274S
c.820G>T
2 papers
NM_000041.4
p.E273A
c.818A>C
1 paper
NM_000041.4
p.E273G
c.818A>G
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