Rho GTPase activating protein 42

TMEM133

FLJ32810

GRAF3

AD031

transmembrane protein 133

Rho GTPase-activating protein 42

Rho GTPase-activating protein 10-like

Rho-type GTPase-activating protein 42

This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017].

Varaico: Literature-Extracted Genetic Variants

ARHGAP42

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol