Rho guanine nucleotide exchange factor 11

KIAA0380

GTRAP48

PDZ-RHOGEF

Rho guanine nucleotide exchange factor (GEF) 11

PDZ-RhoGEF

Regulator of G protein signalling-like domain

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

ARHGEF11

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols