Varaico: Literature-Extracted Genetic Variants

ARHGEF25

57 papers

RefSeq Summary

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which intera...

Pfam Domains

RhoGEFaa 164–334UCSCRhoGEF domain

SOS1_NGEF_PHaa 349–464UCSCSOS1/NGEF-like PH domain

Gene Aliases

HGNC Name

Rho guanine nucleotide exchange factor 25

HGNC Alias Symbols

GEFT; p63RhoGEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182947.4

p.V169I

c.505G>A

Surrounding Variants

1 paper

NM_182947.4

p.M162_V164Fs

c.486_490delinsAFs

1 paper

NM_182947.4

p.L158M

c.472C>A

2 papers

NM_182947.4

p.A146D

c.437C>A

1 paper

NM_182947.4

p.R200Q

c.599G>A

1 paper

NM_182947.4

p.I205N

c.614T>A

1 paper

NM_182947.4

p.Q99L

c.296A>T

1 paper

NM_182947.4

p.H87Y

c.259C>T

1 paper

NM_182947.4

p.Q226L

c.677A>T

1 paper

NM_182947.4

p.R227L

c.680G>T

1 paper

NM_182947.4

p.L78delFs

c.234delG

1 paper

NM_182947.4

p.L78V

c.232C>G

1 paper

NM_182947.4

p.A236V

c.707C>T