Varaico: Literature-Extracted Genetic Variants

ARHGEF25

57 papers

RefSeq Summary

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which intera...

Pfam Domains

RhoGEFaa 164–334UCSCRhoGEF domain

SOS1_NGEF_PHaa 349–464UCSCSOS1/NGEF-like PH domain

Gene Aliases

HGNC Name

Rho guanine nucleotide exchange factor 25

HGNC Alias Symbols

GEFT; p63RhoGEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182947.4

p.Q226L

c.677A>T

Surrounding Variants

1 paper

NM_182947.4

p.R227L

c.680G>T

1 paper

NM_182947.4

p.A236V

c.707C>T

1 paper

NM_182947.4

p.P257L

c.770C>T

1 paper

NM_182947.4

p.V263fs

c.787_788fs

1 paper

NM_182947.4

p.V263delFs

c.788delT

1 paper

NM_182947.4

p.S269G

c.805A>G

1 paper

NM_182947.4

p.I205N

c.614T>A

1 paper

NM_182947.4

p.R200Q

c.599G>A

1 paper

NM_182947.4

p.I289N

c.866T>A

1 paper

NM_182947.4

p.K290N

c.870A>C

1 paper

NM_182947.4

p.K290N

c.870A>T

1 paper

NM_182947.4

p.V169I

c.505G>A