Varaico: Literature-Extracted Genetic Variants

ARHGEF25

57 papers

RefSeq Summary

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which intera...

Pfam Domains

RhoGEFaa 164–334UCSCRhoGEF domain

SOS1_NGEF_PHaa 349–464UCSCSOS1/NGEF-like PH domain

Gene Aliases

HGNC Name

Rho guanine nucleotide exchange factor 25

HGNC Alias Symbols

GEFT; p63RhoGEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_182947.4

p.R332C

c.994C>T

Surrounding Variants

1 paper

NM_182947.4

p.P330L

c.989C>T

1 paper

NM_182947.4

p.D335H

c.1003G>C

1 paper

NM_182947.4

p.T338M

c.1013C>T

1 paper

NM_182947.4

p.D318H

c.952G>C

1 paper

NM_182947.4

p.L372L

c.1116G>A

1 paper

NM_182947.4

p.R380C

c.1138C>T

1 paper

NM_182947.4

p.R399I

c.1196G>T

1 paper

NM_182947.4

p.K290N

c.870A>C

1 paper

NM_182947.4

p.K290N

c.870A>T

1 paper

NM_182947.4

p.I289N

c.866T>A

1 paper

NM_182947.4

p.R429H

c.1286G>A

1 paper

NM_182947.4

p.R429L

c.1286G>T