Varaico: Literature-Extracted Genetic Variants

ARHGEF25

57 papers

RefSeq Summary

Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which intera...

Pfam Domains

RhoGEFaa 164–334UCSCRhoGEF domain

SOS1_NGEF_PHaa 349–464UCSCSOS1/NGEF-like PH domain

Gene Aliases

HGNC Name

Rho guanine nucleotide exchange factor 25

HGNC Alias Symbols

GEFT; p63RhoGEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_182947.4

p.P557H

c.1670C>A

Surrounding Variants

1 paper

NM_182947.4

p.A545G

c.1634C>G

1 paper

NM_182947.4

p.G532V

c.1595G>T

1 paper

NM_182947.4

p.G513_S514insFs

c.1539_1540dupCA

1 paper

NM_182947.4

p.G513S

c.1537G>A

5 papers

NM_182947.4

p.Q506R

c.1517A>G

1 paper

NM_182947.4

p.S501N

c.1502G>A

1 paper

NM_182947.4

p.E480A

c.1439A>C

1 paper

NM_182947.4

p.P478A

c.1432C>G

1 paper

NM_182947.4

p.S477A

c.1429T>G

1 paper

NM_182947.4

p.Q476R

c.1427A>G

1 paper

NM_182947.4

p.K459E

c.1375A>G

1 paper

NM_182947.4

p.P451S

c.1351C>T