Varaico: Literature-Extracted Genetic Variants

ARIH2

44 papers

RefSeq Summary

The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may ...

Pfam Domains

UBA_ARIH2_Naa 66–120UCSCE3 ubiquitin-protein ligase ARIH2, N-terminal UBA domain

zf-C3HC4aa 139–190UCSCZinc finger, C3HC4 type (RING finger)

IBRaa 208–270UCSCIBR domain, a half RING-finger domain

IBR_1aa 292–341UCSCIBR domain

Ariadneaa 363–482UCSCAriadne domain

Gene Aliases

HGNC Name

ariadne RBR E3 ubiquitin protein ligase 2

HGNC Alias Symbol

TRIAD1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006321.4

p.V86A

c.257T>C

Surrounding Variants

1 paper

NM_006321.4

p.V146M

c.436G>A

1 paper

NM_006321.4

p.Q159*

c.475C>T

1 paper

NM_006321.4

p.G180Splc

c.538+9G>A

1 paper

NM_006321.4

p.R191C

c.571C>T

1 paper

NM_006321.4

p.K209R

c.626A>G

1 paper

NM_006321.4

p.R246Q

c.737G>A