Varaico: Literature-Extracted Genetic Variants

ARIH2

44 papers

RefSeq Summary

The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may ...

Pfam Domains

UBA_ARIH2_Naa 66–120UCSCE3 ubiquitin-protein ligase ARIH2, N-terminal UBA domain

zf-C3HC4aa 139–190UCSCZinc finger, C3HC4 type (RING finger)

IBRaa 208–270UCSCIBR domain, a half RING-finger domain

IBR_1aa 292–341UCSCIBR domain

Ariadneaa 363–482UCSCAriadne domain

Gene Aliases

HGNC Name

ariadne RBR E3 ubiquitin protein ligase 2

HGNC Alias Symbol

TRIAD1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_006321.4

p.E382A

c.1145A>C

Surrounding Variants

1 paper

NM_006321.4

p.Y386H

c.1156T>C

1 paper

NM_006321.4

p.R396R

c.1188G>A

1 paper

NM_006321.4

p.V397V

c.1191C>T

1 paper

NM_006321.4

p.W404*

c.1211G>A

1 paper

NM_006321.4

p.W404*

c.1212G>A

1 paper

NM_006321.4

p.N412I

c.1235A>T

1 paper

NM_006321.4

p.T427I

c.1280C>T

1 paper

NM_006321.4

p.Y428N

c.1282T>A

1 paper

NM_006321.4

p.A431T

c.1291G>A

1 paper

NM_006321.4

p.K440N

c.1320G>C

1 paper

NM_006321.4

p.K440N

c.1320G>T

1 paper

NM_006321.4

p.K441N

c.1323G>C