ATPase H+ transporting V0 subunit e1

ATP6H

M9.2

ATPase, H+ transporting, lysosomal (vacuolar proton pump) 9kD

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

V-ATPase subunit e1

V-type proton ATPase subunit e 1

V-ATPase 9.2 kDa membrane accessory protein

V-ATPase M9.2 subunit

Vacuolar proton pump subunit e 1

V-ATPase subunit e 1

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

ATP6V0E1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol