ATPase H+ transporting V1 subunit C1

ATP6D

ATP6C

VATC

Vma5

ATPase, H+ transporting, lysosomal (vacuolar proton pump) 42kD

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1

V-ATPase subunit C1

V-type proton ATPase subunit C 1

Vacuolar proton pump subunit C 1

V-ATPase subunit C 1

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

ATP6V1C1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbols