ATPase H+ transporting V1 subunit H

CGI-11

VMA13

SFDalpha

SFDbeta

ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

vacuolar ATP synthase subunit H

V-ATPase subunit H

V-type proton ATPase subunit H

Nef-binding protein 1

Protein VMA13 homolog

V-ATPase 50/57 kDa subunits

Vacuolar proton pump subunit H

Vacuolar proton pump subunit SFD

NBP1

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Varaico: Literature-Extracted Genetic Variants

ATP6V1H

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols