Varaico: Literature-Extracted Genetic Variants

Gene:BACE1
Variant:p.E53A

BACE1

272 papers

RefSeq Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteol...

Pfam Domains

Aspaa 1–184UCSCEukaryotic aspartyl protease
Aspaa 74–418UCSCEukaryotic aspartyl protease

Gene Aliases

HGNC Name

beta-secretase 1

HGNC Alias Symbol

Asp2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_012104.6
p.E53A
c.158A>C
Surrounding Variants
1 paper
NM_012104.6
p.E53D
c.159G>T
1 paper
NM_012104.6
p.E53D
c.159G>C
1 paper
NM_012104.6
p.E53K
c.157G>A
1 paper
NM_012104.6
p.P54H
c.161C>A
1 paper
NM_012104.6
p.G55G
c.165C>T
1 paper
NM_012104.6
p.R57K
c.170G>A
1 paper
NM_012104.6
p.E49K
c.145G>A
1 paper
NM_012104.6
p.G58S
c.172G>A
1 paper
NM_012104.6
p.F60L
c.178T>C
1 paper
NM_012104.6
p.E46K
c.136G>A
1 paper
NM_012104.6
p.R45P
c.134G>C
1 paper
NM_012104.6
p.M63T
c.188T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."