BAR/IMD domain containing adaptor protein 2 like 1

IRTKS

BAI1 associated protein 2 like 1

insulin receptor tyrosine kinase substrate

BAR/IMD domain-containing adapter protein 2-like 1

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Insulin receptor tyrosine kinase substrate

BAI1-associated protein 2-like protein 1

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009].

Varaico: Literature-Extracted Genetic Variants

BAIAP2L1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol