Varaico: Literature-Extracted Genetic Variants

Gene:BCAR3
Variant:p.A435E

BCAR3

202 papers

RefSeq Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resista...

Pfam Domains

SH2aa 154–234UCSCSH2 domain
RasGEFaa 551–730UCSCRasGEF domain

Gene Aliases

HGNC Name

BCAR3 adaptor protein, NSP family member

HGNC Alias Symbols

NSP2; SH2D3B; AND-34; MIG7

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003567.4
p.A435E
c.1304C>A
Surrounding Variants
2 papers
NM_003567.4
p.L423F
c.1267C>T
1 paper
NM_003567.4
p.P419S
c.1255C>T
2 papers
NM_003567.4
p.S417L
c.1250C>T
1 paper
NM_003567.4
p.P416P
c.1248C>A
1 paper
NM_003567.4
p.K409R
c.1226A>G
1 paper
NM_003567.4
p.E464K
c.1390G>A
2 papers
NM_003567.4
p.P404S
c.1210C>T
1 paper
NM_003567.4
p.P403L
c.1208C>T
1 paper
NM_003567.4
p.D481Y
c.1441G>T
5 papers
NM_003567.4
p.E484Q
c.1450G>C
13 papers
NM_003567.4
p.E484K
c.1450G>A
1 paper
NM_003567.4
p.A386V
c.1157C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."