Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_004333.6

p.R662S

c.1986G>C

Surrounding Variants

2 papers

NM_004333.6

p.R662S

c.1986G>T

3 papers

NM_004333.6

p.D663N

c.1987G>A

1 paper

NM_004333.6

p.R662K

c.1985G>A

1 paper

NM_004333.6

p.D663V

c.1988A>T

1 paper

NM_004333.6

p.D663G

c.1988A>G

1 paper

NM_004333.6

p.R662G

c.1984A>G

2 papers

NM_004333.6

p.D663A

c.1988A>C

2 papers

NM_004333.6

p.N661K

c.1983C>G

1 paper

NM_004333.6

p.D663_Q664ins5

c.1989_1990ins15

1 paper

NM_004333.6

p.D663fs

c.1987_1988fs

2 papers

NM_004333.6

p.N661K

c.1983C>A

1 paper

NM_004333.6

p.Q664K

c.1990C>A