Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

311 papers

NM_004333.6

p.V600M

c.1798G>A

Surrounding Variants

62 papers

NM_004333.6

p.V600L

c.1798G>T

3 papers

NM_004333.6

p.V600ins1

c.1798_1799insCTT

1 paper

NM_004333.6

p.V600ins1

c.1798_1799insATT

1 paper

NM_004333.6

p.V600ins4

c.1798_1799ins12

1 paper

NM_004333.6

p.V600ins3

c.1798_1799ins9

1 paper

NM_004333.6

p.V600ins3

c.1798_1799ins9

1 paper

NM_004333.6

p.V600ins3

c.1798_1799ins9

1 paper

NM_004333.6

p.V600ins2

c.1798_1799ins6

1 paper

NM_004333.6

p.V600insFs

c.1798_1799insC

3 papers

NM_004333.6

p.V600ins1

c.1798_1799insTAC

2 papers

NM_004333.6

p.V600ins2

c.1798_1799ins6

2 papers

NM_004333.6

p.V600ins6

c.1798_1799ins18