Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_004333.6

p.T599T

c.1797A>G

Surrounding Variants

3 papers

NM_004333.6

p.T599T

c.1797A>T

1 paper

NM_004333.6

p.T599delins

c.1797delinsTACT

1 paper

NM_004333.6

p.T599delins

c.1797delinsTACTACG

3 papers

NM_004333.6

p.T599T

c.1797A>C

1 paper

NM_004333.6

p.T599insFs

c.1796dupC

15 papers

NM_004333.6

p.A598_T599ins0

c.1794_1796dupTAC

2 papers

NM_004333.6

p.T599_V600ins3

c.1797_1798ins9

2 papers

NM_004333.6

p.T599_V600ins3

c.1797_1798ins9

4 papers

NM_004333.6

p.A598_T599del1

c.1794_1796delGTA

62 papers

NM_004333.6

p.V600L

c.1798G>T

3 papers

NM_004333.6

p.V600ins1

c.1798_1799insCTT

1 paper

NM_004333.6

p.V600ins1

c.1798_1799insATT