Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.N486_T488del0

c.1457_1462del6

Surrounding Variants

1 paper

NM_004333.6

p.T488I

c.1463C>T

1 paper

NM_004333.6

p.M484_V487del0

c.1450_1461del12

1 paper

NM_004333.6

p.T488_A489insFs

c.1464_1465ins4

1 paper

NM_004333.6

p.L485_T488delins

c.1455_1464delinsT

1 paper

NM_004333.6

p.V487V

c.1461G>T

1 paper

NM_004333.6

p.A489T

c.1465G>A

1 paper

NM_004333.6

p.T488delFs

c.1462_1463delGT

1 paper

NM_004333.6

p.T488del1

c.1462_1463delTGT

2 papers

NM_004333.6

p.A489fs

c.1465_1466fs

18 papers

NM_004333.6

p.V487G

c.1460T>G

1 paper

NM_004333.6

p.V487A

c.1460T>C

1 paper

NM_004333.6

p.V487E

c.1460T>A