Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_004333.6

p.T470R

c.1409C>G

Surrounding Variants

1 paper

NM_004333.6

p.T470I

c.1409C>T

2 papers

NM_004333.6

p.T470K

c.1409C>A

1 paper

NM_004333.6

p.T470delFs

c.1408delT

3 papers

NM_004333.6

p.T470A

c.1408A>G

7 papers

NM_004333.6

p.T470P

c.1408A>C

4 papers

NM_004333.6

p.G469del1

c.1405_1406delTCC

1 paper

NM_004333.6

p.S467_G469del3

c.1399_1406del9

64 papers

NM_004333.6

p.V471F

c.1411G>T

1 paper

NM_004333.6

p.T470ins0

c.1408_1410dupACA

16 papers

NM_004333.6

p.V471I

c.1411G>A

2 papers

NM_004333.6

p.T470del1

c.1408_1409delTGT

2 papers

NM_004333.6

p.G469G

c.1407A>T