Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.M438V

c.1312A>G

Surrounding Variants

2 papers

NM_004333.6

p.M438I

c.1314G>T

2 papers

NM_004333.6

p.M438I

c.1314G>C

2 papers

NM_004333.6

p.M438I

c.1314G>A

1 paper

NM_004333.6

p.M438_K439Splc

c.1314+1G>A

1 paper

NM_004333.6

p.R437*

c.1309C>T

1 paper

NM_004333.6

p.R437G

c.1309C>G

2 papers

NM_004333.6

p.R435S

c.1305G>T

1 paper

NM_004333.6

p.R435S

c.1305G>C

1 paper

NM_004333.6

p.D434_R435del1

c.1302_1304delCTG

2 papers

NM_004333.6

p.R435T

c.1304G>C

1 paper

NM_004333.6

p.R435K

c.1304G>A

1 paper

NM_004333.6

p.R435delFs

c.1303delT