Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.S405A

c.1213T>G

Surrounding Variants

1 paper

NM_004333.6

p.S405_L406insC

c.1213_1217ins3

1 paper

NM_004333.6

p.S405L

c.1214C>T

4 papers

NM_004333.6

p.A404fs

c.1210_1211fs

1 paper

NM_004333.6

p.S405S

c.1215A>T

1 paper

NM_004333.6

p.S405fs

c.1213_1214fs

1 paper

NM_004333.6

p.A404P

c.1210G>C

2 papers

NM_004333.6

p.P403delFs

c.1209delA

10 papers

NM_004333.6

p.A404fs

c.1210_1211fs

7 papers

NM_004333.6

p.P403insFs

c.1208dupC

2 papers

NM_004333.6

p.P403insFs

c.1207_1208dupCC

20 papers

NM_004333.6

p.P403fs

c.1207_1208fs

1 paper

NM_004333.6

p.L406*

c.1217T>G