Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.L286L

c.858T>G

Surrounding Variants

2 papers

NM_004333.6

p.L286P

c.857T>C

1 paper

NM_004333.6

p.D287_L288ins5

c.859_863ins15

2 papers

NM_004333.6

p.D287H

c.859G>C

2 papers

NM_004333.6

p.L286F

c.856C>T

1 paper

NM_004333.6

p.L286V

c.856C>G

1 paper

NM_004333.6

p.Q285delFs

c.854delT

1 paper

NM_004333.6

p.Q285*

c.853C>T

1 paper

NM_004333.6

p.D284delFs

c.851_852delGT

1 paper

NM_004333.6

p.D284D

c.852C>T

1 paper

NM_004333.6

p.D284Y

c.850G>T

1 paper

NM_004333.6

p.Y283Y

c.849T>C

1 paper

NM_004333.6

p.Y283C

c.848A>G