Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.E275D

c.825A>T

Surrounding Variants

1 paper

NM_004333.6

p.E275D

c.825A>C

1 paper

NM_004333.6

p.V276L

c.826G>C

1 paper

NM_004333.6

p.V276I

c.826G>A

10 papers

NM_004333.6

p.E275K

c.823G>A

1 paper

NM_004333.6

p.T274T

c.822A>T

1 paper

NM_004333.6

p.T274T

c.822A>G

2 papers

NM_004333.6

p.T274I

c.821C>T

1 paper

NM_004333.6

p.P277S

c.829C>T

2 papers

NM_004333.6

p.P277A

c.829C>G

1 paper

NM_004333.6

p.T274K

c.821C>A

1 paper

NM_004333.6

p.P277L

c.830C>T

1 paper

NM_004333.6

p.P277Q

c.830C>A