Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.T274A

c.820A>G

Surrounding Variants

1 paper

NM_004333.6

p.T274P

c.820A>C

2 papers

NM_004333.6

p.T274I

c.821C>T

1 paper

NM_004333.6

p.T274K

c.821C>A

1 paper

NM_004333.6

p.S273I

c.818G>T

14 papers

NM_004333.6

p.S273N

c.818G>A

1 paper

NM_004333.6

p.C272_S273delFs

c.816_817delTA

1 paper

NM_004333.6

p.T274T

c.822A>T

1 paper

NM_004333.6

p.T274T

c.822A>G

10 papers

NM_004333.6

p.E275K

c.823G>A

1 paper

NM_004333.6

p.S273G

c.817A>G

1 paper

NM_004333.6

p.E275D

c.825A>T

1 paper

NM_004333.6

p.E275D

c.825A>C