Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.F259delins

c.775_777delinsCAA

Surrounding Variants

4 papers

NM_004333.6

p.F259L

c.777C>G

4 papers

NM_004333.6

p.F259L

c.777C>A

4 papers

NM_004333.6

p.R260C

c.778C>T

5 papers

NM_004333.6

p.F259L

c.775T>C

1 paper

NM_004333.6

p.R260L

c.779G>T

4 papers

NM_004333.6

p.R260P

c.779G>C

3 papers

NM_004333.6

p.R260H

c.779G>A

1 paper

NM_004333.6

p.C261G

c.781T>G

1 paper

NM_004333.6

p.R260delFs

c.780delG

6 papers

NM_004333.6

p.G258V

c.773G>T

1 paper

NM_004333.6

p.G258D

c.773G>A

1 paper

NM_004333.6

p.G258C

c.772G>T