Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.L245V

c.733T>G

Surrounding Variants

1 paper

NM_004333.6

p.L245I

c.733T>A

1 paper

NM_004333.6

p.T244T

c.732C>T

1 paper

NM_004333.6

p.T244T

c.732C>A

1 paper

NM_004333.6

p.F243_T244delFs

c.729_730delTG

1 paper

NM_004333.6

p.T244I

c.731C>T

40 papers

NM_004333.6

p.L245F

c.735A>T

1 paper

NM_004333.6

p.L245L

c.735A>G

39 papers

NM_004333.6

p.L245F

c.735A>C

41 papers

NM_004333.6

p.A246P

c.736G>C

1 paper

NM_004333.6

p.A246T

c.736G>A

1 paper

NM_004333.6

p.L245delFs

c.735delT

1 paper

NM_004333.6

p.T244A

c.730A>G