Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.K164N

c.492A>T

Surrounding Variants

1 paper

NM_004333.6

p.K164K

c.492A>G

2 papers

NM_004333.6

p.K164N

c.492A>C

4 papers

NM_004333.6

p.P162_K164del0

c.486_491del6

3 papers

NM_004333.6

p.Q165*

c.493C>T

1 paper

NM_004333.6

p.N163_K164Fs

c.487_492delinsAFs

1 paper

NM_004333.6

p.K164R

c.491A>G

1 paper

NM_004333.6

p.P162_K164delFs

c.486_490del5

1 paper

NM_004333.6

p.Q165R

c.494A>G

1 paper

NM_004333.6

p.Q165H

c.495G>T

1 paper

NM_004333.6

p.Q165H

c.495G>C

1 paper

NM_004333.6

p.N163K

c.489C>A

1 paper

NM_004333.6

p.N163delins

c.488_489delinsGT