Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_004333.6

p.V157A

c.470T>C

Surrounding Variants

1 paper

NM_004333.6

p.V157G

c.470T>G

5 papers

NM_004333.6

p.V157D

c.470T>A

1 paper

NM_004333.6

p.V157fs

c.469_470fs

1 paper

NM_004333.6

p.I156_V157del1

c.467_469delCGA

17 papers

NM_004333.6

p.V157F

c.469G>T

1 paper

NM_004333.6

p.V157L

c.469G>C

653 papers

NM_004333.6

p.V157I

c.469G>A

1 paper

NM_004333.6

p.I156I

c.468C>T

2 papers

NM_004333.6

p.R158*

c.472A>T

1 paper

NM_004333.6

p.R158Fs

c.472delinsTTFs

2 papers

NM_004333.6

p.R158G

c.472A>G

3 papers

NM_004333.6

p.R158K

c.473G>A