Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.P132R

c.395C>G

Surrounding Variants

1 paper

NM_004333.6

p.P132_S133insFs

c.396_397insAC

1 paper

NM_004333.6

p.P132P

c.396T>A

6 papers

NM_004333.6

p.P132S

c.394C>T

2 papers

NM_004333.6

p.P132A

c.394C>G

1 paper

NM_004333.6

p.L131insFs

c.393dupA

2 papers

NM_004333.6

p.P132T

c.394C>A

1 paper

NM_004333.6

p.S133P

c.397T>C

1 paper

NM_004333.6

p.L131L

c.393A>G

1 paper

NM_004333.6

p.L131R

c.392T>G

2 papers

NM_004333.6

p.S133L

c.398C>T

1 paper

NM_004333.6

p.L131L

c.391C>T

1 paper

NM_004333.6

p.V130_L131insFs

c.390_391ins4