Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.V111Fs

c.331delinsCCTGGFs

Surrounding Variants

1 paper

NM_004333.6

p.V111L

c.331G>C

1 paper

NM_004333.6

p.V111G

c.332T>G

1 paper

NM_004333.6

p.V111A

c.332T>C

1 paper

NM_004333.6

p.S110insFs

c.328dupT

1 paper

NM_004333.6

p.F109fs

c.325_326fs

3 papers

NM_004333.6

p.S112F

c.335C>T

2 papers

NM_004333.6

p.S112C

c.335C>G

1 paper

NM_004333.6

p.S112ins1

c.335_336insTGA

1 paper

NM_004333.6

p.F109C

c.326T>G

1 paper

NM_004333.6

p.S112S

c.336T>C

1 paper

NM_004333.6

p.F109S

c.326T>C

1 paper

NM_004333.6

p.F109V

c.325T>G