Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.T107N

c.320C>A

Surrounding Variants

1 paper

NM_004333.6

p.T107I

c.320C>T

1 paper

NM_004333.6

p.L100_N105delFs

c.300_315del16

1 paper

NM_004333.6

p.T107A

c.319A>G

1 paper

NM_004333.6

p.T107delins

c.319delinsTGCTGGTTTGACA

1 paper

NM_004333.6

p.D108Y

c.322G>T

1 paper

NM_004333.6

p.D108H

c.322G>C

1 paper

NM_004333.6

p.D108N

c.322G>A

5 papers

NM_004333.6

p.G106V

c.317G>T

2 papers

NM_004333.6

p.G106E

c.317G>A

1 paper

NM_004333.6

p.D108insFs

c.323_324ins40

1 paper

NM_004333.6

p.D108insFs

c.323_324insCA

2 papers

NM_004333.6

p.G106*

c.316G>T