Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.S87N

c.260G>A

Surrounding Variants

3 papers

NM_004333.6

p.K88E

c.262A>G

1 paper

NM_004333.6

p.K88Q

c.262A>C

1 paper

NM_004333.6

p.T86delFs

c.256delT

1 paper

NM_004333.6

p.K88N

c.264G>T

1 paper

NM_004333.6

p.K88N

c.264G>C

1 paper

NM_004333.6

p.K88K

c.264G>A

2 papers

NM_004333.6

p.L89L

c.265C>T

1 paper

NM_004333.6

p.Y85*

c.255C>G

2 papers

NM_004333.6

p.Y85*

c.255C>A

1 paper

NM_004333.6

p.L89I

c.265C>A

1 paper

NM_004333.6

p.T86_K88del3

c.256_263del9

1 paper

NM_004333.6

p.L89fs

c.265_266fs