Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.A81_Y82insFs

c.243_244insC

Surrounding Variants

1 paper

NM_004333.6

p.Y82_E83insCG

c.244_248ins6

1 paper

NM_004333.6

p.Y82D

c.244T>G

1 paper

NM_004333.6

p.Y82N

c.244T>A

3 papers

NM_004333.6

p.A81A

c.243C>T

1 paper

NM_004333.6

p.A81A

c.243C>A

4 papers

NM_004333.6

p.A81V

c.242C>T

2 papers

NM_004333.6

p.A81G

c.242C>G

1 paper

NM_004333.6

p.E83*

c.247G>T

2 papers

NM_004333.6

p.A81P

c.241G>C

1 paper

NM_004333.6

p.E83K

c.247G>A

1 paper

NM_004333.6

p.A81T

c.241G>A

2 papers

NM_004333.6

p.E83V

c.248A>T