Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.H60_I61delins

c.180_181delinsTA

Surrounding Variants

1 paper

NM_004333.6

p.I61T

c.182T>C

19 papers

NM_004333.6

p.I61I

c.183A>T

1 paper

NM_004333.6

p.I61delins

c.181_182delinsTT

3 papers

NM_004333.6

p.I61V

c.181A>G

2 papers

NM_004333.6

p.I61M

c.183A>G

25 papers

NM_004333.6

p.I61I

c.183A>C

1 paper

NM_004333.6

p.I61delins

c.181_183delinsAAG

1 paper

NM_004333.6

p.L56_H60del0

c.166_180del15

2 papers

NM_004333.6

p.H60_I61delins

c.180_181delinsCA

5 papers

NM_004333.6

p.H60_I61delins

c.180_181delinsAA

1 paper

NM_004333.6

p.K55_H60del0

c.165_179del15

1 paper

NM_004333.6

p.E62*

c.184G>T