Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.A27_A34del8

c.79_101del24

Surrounding Variants

2 papers

NM_004333.6

p.S36_S37insGGT

c.106_110ins9

3 papers

NM_004333.6

p.S36A

c.106T>G

3 papers

NM_004333.6

p.S36F

c.107C>T

1 paper

NM_004333.6

p.S36C

c.107C>G

1 paper

NM_004333.6

p.A35A

c.105C>G

2 papers

NM_004333.6

p.S36S

c.108T>A

2 papers

NM_004333.6

p.A35V

c.104C>T

2 papers

NM_004333.6

p.G32_A34del3

c.94_101del9

1 paper

NM_004333.6

p.G30_A34del5

c.88_101del15

1 paper

NM_004333.6

p.E26_A34del9

c.76_101del27

7 papers

NM_004333.6

p.S37A

c.109T>G

3 papers

NM_004333.6

p.A34ins2

c.100_101ins6