Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_004333.6

p.A34V

c.101C>T

Surrounding Variants

3 papers

NM_004333.6

p.A34G

c.101C>G

8 papers

NM_004333.6

p.G32_A34ins1

c.95_100dup6

1 paper

NM_004333.6

p.A34E

c.101C>A

7 papers

NM_004333.6

p.G32_A34del0

c.95_100del6

2 papers

NM_004333.6

p.G28_A31del4

c.82_92del12

2 papers

NM_004333.6

p.A34S

c.100G>T

2 papers

NM_004333.6

p.A34fs

c.100_101fs

4 papers

NM_004333.6

p.A34P

c.100G>C

3 papers

NM_004333.6

p.A34T

c.100G>A

2 papers

NM_004333.6

p.A34A

c.102G>A

1 paper

NM_004333.6

p.A33del1

c.97_98delGGC

1 paper

NM_004333.6

p.A27_A34del0

c.81_101del21