Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004333.6

p.M23K

c.68T>A

Surrounding Variants

1 paper

NM_004333.6

p.M23I

c.69G>C

1 paper

NM_004333.6

p.M23I

c.69G>A

1 paper

NM_004333.6

p.M23V

c.67A>G

1 paper

NM_004333.6

p.E24*

c.70G>T

2 papers

NM_004333.6

p.E24K

c.70G>A

1 paper

NM_004333.6

p.M23del1

c.67_68delCAT

2 papers

NM_004333.6

p.F19_M23del5

c.55_68del15

2 papers

NM_004333.6

p.D22E

c.66C>G

2 papers

NM_004333.6

p.D22E

c.66C>A

2 papers

NM_004333.6

p.D22V

c.65A>T

1 paper

NM_004333.6

p.E24V

c.71A>T

4 papers

NM_004333.6

p.D22G

c.65A>G