Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_004333.6

p.D22G

c.65A>G

Surrounding Variants

2 papers

NM_004333.6

p.D22V

c.65A>T

2 papers

NM_004333.6

p.D22A

c.65A>C

1 paper

NM_004333.6

p.D22Y

c.64G>T

1 paper

NM_004333.6

p.D22H

c.64G>C

49 papers

NM_004333.6

p.D22N

c.64G>A

2 papers

NM_004333.6

p.D22E

c.66C>G

2 papers

NM_004333.6

p.D22E

c.66C>A

1 paper

NM_004333.6

p.M23V

c.67A>G

1 paper

NM_004333.6

p.M23K

c.68T>A

2 papers

NM_004333.6

p.G21R

c.61G>C

1 paper

NM_004333.6

p.M23I

c.69G>C

3 papers

NM_004333.6

p.G21R

c.61G>A