Varaico: Literature-Extracted Genetic Variants

BRAF

18,221 papers

RefSeq Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, ...

Pfam Domains

RBDaa 156–227UCSCRaf-like Ras-binding domain

C1_1aa 235–282UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 497–754UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

B-Raf proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

BRAF1; BRAF-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_004333.6

p.A3V

c.8C>T

Surrounding Variants

2 papers

NM_004333.6

p.A3E

c.8C>A

1 paper

NM_004333.6

p.A3delFs

c.7delC

1 paper

NM_004333.6

p.A3A

c.9G>T

1 paper

NM_004333.6

p.A3S

c.7G>T

1 paper

NM_004333.6

p.A3_L4insFs

c.9_10insT

1 paper

NM_004333.6

p.A3A

c.9G>C

1 paper

NM_004333.6

p.A3P

c.7G>C

1 paper

NM_004333.6

p.A3A

c.9G>A

1 paper

NM_004333.6

p.A3T

c.7G>A

1 paper

NM_004333.6

p.A2A

c.6G>T

1 paper

NM_004333.6

p.A2insFs

c.5dupC

1 paper

NM_004333.6

p.A2fs

c.4_5fs