Varaico: Literature-Extracted Genetic Variants

Gene:CASP10
Variant:p.R21C

CASP10

247 papers

RefSeq Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. ...

Pfam Domains

DEDaa 20–101UCSCDeath effector domain
DEDaa 115–191UCSCDeath effector domain
Peptidase_C14aa 283–505UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 10

HGNC Alias Symbols

MCH4; FLICE-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_032977.4
p.R21C
c.61C>T
Surrounding Variants
1 paper
NM_032977.4
p.V18M
c.52G>A
1 paper
NM_032977.4
p.K17R
c.50A>G
1 paper
NM_032977.4
p.C16Y
c.47G>A
1 paper
NM_032977.4
p.C16F
c.47G>T
2 papers
NM_032977.4
p.N15_C16insFs
c.45_46insT
1 paper
NM_032977.4
p.N15S
c.44A>G
4 papers
NM_032977.4
p.K14T
c.41A>C
1 paper
NM_032977.4
p.D13Y
c.37G>T
1 paper
NM_032977.4
p.N30Y
c.88A>T
1 paper
NM_032977.4
p.S11N
c.32G>A
1 paper
NM_032977.4
p.S11ins1
c.32_33insCTC
1 paper
NM_032977.4
p.G32R
c.94G>A
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