Varaico: Literature-Extracted Genetic Variants

Gene:CASP10
Variant:p.R109*

CASP10

247 papers

RefSeq Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. ...

Pfam Domains

DEDaa 20–101UCSCDeath effector domain
DEDaa 115–191UCSCDeath effector domain
Peptidase_C14aa 283–505UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 10

HGNC Alias Symbols

MCH4; FLICE-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_032977.4
p.R109*
c.325C>T
Surrounding Variants
1 paper
NM_032977.4
p.R111T
c.332G>C
1 paper
NM_032977.4
p.V112del1
c.334_336delGTT
1 paper
NM_032977.4
p.V112I
c.334G>A
1 paper
NM_032977.4
p.L114L
c.340C>T
1 paper
NM_032977.4
p.E100G
c.299A>G
1 paper
NM_032977.4
p.E100fs
c.298_299fs
1 paper
NM_032977.4
p.K99_E100delFs
c.297_298delAG
2 papers
NM_032977.4
p.K99E
c.295A>G
1 paper
NM_032977.4
p.T98A
c.292A>G
1 paper
NM_032977.4
p.R87W
c.259C>T
1 paper
NM_032977.4
p.A80P
c.238G>C
1 paper
NM_032977.4
p.F78F
c.234C>T
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