Varaico: Literature-Extracted Genetic Variants

Gene:CASP10
Variant:p.I406L

CASP10

247 papers

RefSeq Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. ...

Pfam Domains

DEDaa 20–101UCSCDeath effector domain
DEDaa 115–191UCSCDeath effector domain
Peptidase_C14aa 283–505UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 10

HGNC Alias Symbols

MCH4; FLICE-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
20 papers
NM_032977.4
p.I406L
c.1216A>T
Surrounding Variants
20 papers
NM_032977.4
p.I406L
c.1216A>C
44 papers
NM_032977.4
p.V410I
c.1228G>A
2 papers
NM_032977.4
p.C401S
c.1202G>C
2 papers
NM_032977.4
p.C401S
c.1201T>A
1 paper
NM_032977.4
p.C401fs
c.1201_1202fs
3 papers
NM_032977.4
p.C401fs
c.1201_1202fs
5 papers
NM_032977.4
p.C401_G403delFs
c.1202_1208del7
1 paper
NM_001206524.2
p.C334_G336del3
c.1000_1007del9
1 paper
NM_032977.4
p.A400S
c.1198G>T
1 paper
NM_032977.4
p.E413K
c.1237G>A
1 paper
NM_032977.4
p.E413D
c.1239A>C
1 paper
NM_032977.4
p.A414V
c.1241C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."