Varaico: Literature-Extracted Genetic Variants

Gene:CASP10
Variant:p.F449F

CASP10

247 papers

RefSeq Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. ...

Pfam Domains

DEDaa 20–101UCSCDeath effector domain
DEDaa 115–191UCSCDeath effector domain
Peptidase_C14aa 283–505UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 10

HGNC Alias Symbols

MCH4; FLICE-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_032977.4
p.F449F
c.1347T>C
Surrounding Variants
1 paper
NM_032977.4
p.R450W
c.1348C>T
20 papers
NM_032977.4
p.Y446C
c.1337A>G
1 paper
NM_032977.4
p.G445D
c.1334G>A
1 paper
NM_032977.4
p.C463S
c.1387T>A
1 paper
NM_032977.4
p.C463S
c.1388G>C
1 paper
NM_032977.4
p.E433A
c.1298A>C
1 paper
NM_032977.4
p.E433K
c.1297G>A
1 paper
NM_032977.4
p.K468Fs
c.1404delinsACFs
1 paper
NM_032977.4
p.A422G
c.1265C>G
1 paper
NM_032977.4
p.E420E
c.1260G>A
1 paper
NM_032977.4
p.A414V
c.1241C>T
1 paper
NM_032977.4
p.E413D
c.1239A>C
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