Varaico: Literature-Extracted Genetic Variants

Gene:CASP10
Variant:p.L517L

CASP10

247 papers

RefSeq Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. ...

Pfam Domains

DEDaa 20–101UCSCDeath effector domain
DEDaa 115–191UCSCDeath effector domain
Peptidase_C14aa 283–505UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 10

HGNC Alias Symbols

MCH4; FLICE-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_032977.4
p.L517L
c.1551G>A
Surrounding Variants
7 papers
NM_032977.4
p.L522I
c.1564T>A
1 paper
NM_032977.4
p.L511Fs
c.1533delinsACFs
1 paper
NM_032977.4
p.P503L
c.1508C>T
6 papers
NM_032977.4
p.P501L
c.1502C>T
2 papers
NM_032977.4
p.Q502delFs
c.1504delC
2 papers
NM_032977.4
p.V491insFs
c.1472_1473insA
1 paper
NM_032977.4
p.V487A
c.1460T>C
1 paper
NM_032977.4
p.T481I
c.1442C>T
1 paper
NM_032977.4
p.R472Splc
c.1416-3737C>T
1 paper
NM_032977.4
p.R472Splc
c.1416-3804T>C
1 paper
NM_032977.4
p.K468Fs
c.1404delinsACFs
1 paper
NM_032977.4
p.C463S
c.1388G>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."