Varaico: Literature-Extracted Genetic Variants

Gene:CASP3
Variant:p.L157I

CASP3

926 papers

RefSeq Summary

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) p...

Pfam Domains

Peptidase_C14aa 44–274UCSCCaspase domain

Gene Aliases

HGNC Name

caspase 3

HGNC Alias Symbols

CPP32; CPP32B; Yama; apopain

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_004346.4
p.L157I
c.469C>A
Surrounding Variants
1 paper
NM_004346.4
p.L157F
c.469C>T
2 papers
NM_004346.4
p.K156I
c.467A>T
1 paper
NM_004346.4
p.F158L
c.472T>C
1 paper
NM_004346.4
p.F158L
c.474C>G
1 paper
NM_004346.4
p.F158L
c.474C>A
1 paper
NM_004346.4
p.P155H
c.464C>A
1 paper
NM_004346.4
p.K154insFs
c.460dupA
1 paper
NM_004346.4
p.P155fs
c.463_464fs
2 papers
NM_004346.4
p.I160F
c.478A>T
1 paper
NM_004346.4
p.G153V
c.458G>T
1 paper
NM_004346.4
p.T152A
c.454A>G
1 paper
NM_004346.4
p.Q161_A162Splc
c.483+2T>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."