caspase 5

ICE(rel)III

caspase 5, apoptosis-related cysteine protease

caspase 5, apoptosis-related cysteine peptidase

Caspase-5

ICE(rel)-III

Protease ICH-3

Protease TY

Caspase-5 subunit p20

Caspase-5 subunit p10

CASP-5

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010].

Varaico: Literature-Extracted Genetic Variants

CASP5

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol