cellular communication network factor 4

WISP1-OT1

WISP1-UT1

WISP1

WISP-1

WISP1 overlapping transcript 1

WISP1 3'UTR-associated RNA 1

WNT1 inducible signaling pathway protein 1

CCN family member 4

WNT1-inducible-signaling pathway protein 1

Wnt-1-induced secreted protein

Insulin-like growth factor binding protein

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011].

Varaico: Literature-Extracted Genetic Variants

CCN4

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbols