Varaico: Literature-Extracted Genetic Variants

CD4

453 papers

RefSeq Summary

This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presen...

Pfam Domains

igaa 27–122UCSCImmunoglobulin domain

C2-setaa 125–203UCSCImmunoglobulin C2-set domain

CD4-extracelaa 206–316UCSCCD4, extracellular

C2-setaa 317–390UCSCImmunoglobulin C2-set domain

Tcell_CD4_Caa 402–449UCSCT cell CD4 receptor C terminal region

Gene Aliases

HGNC Name

CD4 molecule

HGNC Alias Symbols

T4; Leu-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000616.5

p.S375A

c.1123T>G

Surrounding Variants

4 papers

NM_000616.5

p.S375W

c.1124C>G

1 paper

NM_000616.5

p.E381Q

c.1141G>C

1 paper

NM_000616.5

p.E381A

c.1142A>C

1 paper

NM_000616.5

p.E364G

c.1091A>G

1 paper

NM_000616.5

p.V386Splc

c.1156+2T>C

1 paper

NM_000616.5

p.L361L

c.1081C>T

1 paper

NM_000616.5

p.W359fs

c.1075_1076fs

1 paper

NM_000616.5

p.V358V

c.1074G>A

1 paper

NM_000616.5

p.W359insFs

c.1075_1076dupTG

1 paper

NM_000616.5

p.K356N

c.1068G>C

1 paper

NM_000616.5

p.K356N

c.1068G>T

1 paper

NM_000616.5

p.E355G

c.1064A>G